Preparation of vinylogous 2-sulfonylindolines by the palladium-catalyzed heteroannulation of o-iodoanilines with dienyl sulfones and their further transformation to …

…, RJ Bethell, M Parvez, JA Taylor

Index: Back; Bethell; Parvez; Taylor Journal of Organic Chemistry, 2001 , vol. 66, # 25 p. 8599 - 8605

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Citation Number: 29

Abstract

The palladium-catalyzed heteroannulation of o-iodoanilines with dienyl sulfones provides a convenient route to vinylogous 2-sulfonylindolines 3. The reaction proceeds in DMF/water in the presence of potassium carbonate and catalytic palladium (II) acetate and is compatible with both electron-donating and-withdrawing substituents in the para position of the aniline, and with an alkyl substituent at C-2 of the dienyl sulfone. The indolines underwent ...