e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Studies on pyrazolo [3, 4-d] pyrimidine derivatives. XV. Reactions involving the formation of the anion of the Reissert compound derived from 1H-pyrazolo [3, 4-d] …
The anion (A) of the Reissert compound (1, 5-benzoyl-4, 5-dihydro-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidine-4-carbonitrile) was found to react with electrophiles in two ways. One is nucleophilic attack of the anion A. The other is self-decomposition of the anion A. Thus, A underwent nucleophilic attack with aromatic and aliphatic aldehydes (4a-j), resulting in the formation of the corresponding α-aryl (or alkyl)-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4- ...
![5-benzoyl-4,5-dihydro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4-carbonitrile Structure](https://image.chemsrc.com/caspic/150/110212-00-5.png)
![1-phenylpyrazolo[3,4-d]pyrimidine Structure](https://image.chemsrc.com/caspic/140/53645-79-7.png)
![5,7-dibenzoyl-4-methyl-1-phenyl-4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine-6-carbonitrile Structure](https://image.chemsrc.com/caspic/355/115393-20-9.png)
![(2-methoxy-phenyl)-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanone Structure](https://image.chemsrc.com/caspic/372/59563-52-9.png)
![4-(2,4-dinitrophenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Structure](https://image.chemsrc.com/caspic/210/115393-19-6.png)
![1-phenylpyrazolo[3,4-d]pyrimidine-4-carbonitrile Structure](https://image.chemsrc.com/caspic/115/65143-08-0.png)
