. beta. 1-Selective adrenoceptor antagonists. 1. Synthesis and. beta.-adrenergic blocking activity of a series of binary (aryloxy) propanolamines

RW Kierstead, A Faraone, F Mennona…

Index: Kierstead, R. W.; Faraone, A.; Mennona, F.; Mullin, J.; Guthrie, R. W.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1561 - 1569

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Citation Number: 75

Abstract

A series of binary (ary1oxy) propanolamines has been prepared and examined in vitro and in vivo for@-adrenoreceptor blocking activity. These symmetrical compounds consist of two (S)-(pheny1oxy) propanolamine pharmacophores coupled through alkylenedioxy or poly (oxyethy1enedioxy) linking units of varying lengths. Examples of such binary compounds linked through the 2, 2', 3, 3', and 4, 4'positions in the aromatic rings of the ...