Tetrahedron Letters

Dithiocarbamate as an efficient intermediate for the synthesis of 2-amino-1, 3, 4-thiadiazoles in water

F Aryanasab, AZ Halimehjani, MR Saidi

Index: Aryanasab, Fezzeh; Halimehjani, Azim Ziyaei; Saidi, Mohammad R. Tetrahedron Letters, 2010 , vol. 51, # 5 p. 790 - 792

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Citation Number: 29

Abstract

A new and facile protocol for the synthesis of 2-amino-1, 3, 4-thiadiazoles in water is described. Reaction of acid hydrazides with easily prepared dithiocarbamates gives the corresponding thiadiazoles in moderate to excellent yields. 2-Amino-1, 3, 4-oxadiazoles were not observed as side products using this procedure.