Liposomes as carriers for colchicine-derived prodrugs: Vascular disrupting nanomedicines with tailorable drug release kinetics

BJ Crielaard, S van der Wal, HT Le, ATL Bode…

Index: Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435

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Citation Number: 21

Abstract

Newly formed tumor vasculature has proven to be an effective target for tumor therapy. A strategy to attack this angiogenic tumor vasculature is to initiate local blood vessel congestion and consequently induce massive tumor cell necrosis. Vascular disrupting agents (VDAs) typically bind to tubulin and consequently disrupt microtubule dynamics. Colchicine and its derivatives (colchicinoids) are very potent tubulin binding compounds ...