The Journal of Organic Chemistry

Enantiocontrolled synthesis of burseran, brassilignan, dehydroxycubebin, and other tetrahydrofuran lignans in both enantiomeric forms. Application of intermolecular …

JA Gaboury, MP Sibi

Index: Gaboury, Janet A.; Sibi, Mukund P. Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2173 - 2180

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Citation Number: 32

Abstract

Lignan natural products have been of interest because of their wide spread occurrence, varied biological activity, and use in folk medicine.'Several members of this family of natural products and their analogs have been shown to possess potent antitumor properties. One class of antitumor agents, called the spindle poisom, are compounds whose mode of action is prevention of the normal function of the mitotic spindle. Natural products colchicine, ...