Cytotoxic activities of novel hexahydroindolizino [8, 7-b] indole derivatives prepared by 1, 3-dipolar cycloaddition reactions of 3, 4-dihydro-β-carboline ylides

M Bertrand, G Poissonnet, MH Théret-Bettiol…

Index: Bertrand, Martial; Poissonnet, Guillaume; Theret-Bettiol, Marie-Helene; Gaspard, Christiane; Werner, Georges H.; Pfeiffer, Bruno; Renard, Pierre; Leonce, Stephane; Dodd, Robert H. Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2155 - 2164

Full Text: HTML

Citation Number: 12

Abstract

A series of 1-cyano and 2-cyanohexahydroindolizino [8, 7-b] indole derivatives was prepared by 1, 3-dipolar cycloaddition of acrylonitrile with ylides derived from 3, 4-dihydro-β- carboline and its 6-methoxy, 6-benzyloxy, 9-methyl and 9-benzyl analogues. The products, together with their reduced 1-or 2-aminomethyl derivatives, were evaluated for cytotoxic activity in L1210 cancer cells. Compounds derived from 6-benzyloxy or 9-benzyl-3, 4- ...