Synthesis and biological evaluation of 4-(1, 2, 3-triazol-1-yl) coumarin derivatives as potential antitumor agents

…, X Hou, H Luo, H Liu, X Han, G Yan, Z Ding, R Li

Index: Zhang, Wenjuan; Li, Zhi; Zhou, Meng; Wu, Feng; Hou, Xueyan; Luo, Hao; Liu, Hao; Han, Xuan; Yan, Guoyi; Ding, Zhenyu; Li, Rui Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 799 - 807

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Citation Number: 44

Abstract

Abstract In this research, a series of 4-(1, 2, 3-triazol-1-yl) coumarin conjugates were synthesized and their anticancer activities were evaluated in vitro against three human cancer cell lines, including human breast carcinoma MCF-7 cell, colon carcinoma SW480 cell and lung carcinoma A549 cell. To increase the biological potency, structural optimization campaign was conducted focusing on the C-4 position of 1, 2, 3-triazole and ...