Synthesis and reactions of quinoxaline derivatives

…, GM El-Naggar, HAH El-Sherief, SA Mahgoub

Index: Badr; El-Naggar; El-Sherief; Mahgoub Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 6 p. 1653 - 1657

Full Text: HTML

Citation Number: 14

Abstract

Reaction of 3-methyl-2 (1H) quinoxalinone (1) with alkyl, benzyl, and arenesulfonyl halides in the presence of K 2 CO 3 in dry acetone gave 1-substituted 3-methyl-2 (1H)- quinoxalinones (2a–g). However 1 reacts with benzoyl chloride under the same conditions to give 3-methyl-2-quinoxalinyl benzoate, while it reacts with P 2 S 5 in dry pyridine to give 3- methyl-2 (1H) quinoxalinethione (4). Treatment of 4 with methy iodide in the presence of K ...