One-pot Negishi cross-coupling reactions of in situ generated zinc reagents with aryl chlorides, bromides, and triflates

S Sase, M Jaric, A Metzger, V Malakhov…

Index: Sase, Shohei; Jaric, Milica; Metzger, Albrecht; Malakhov, Vladimir; Knochel, Paul Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7380 - 7382

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Citation Number: 102

Abstract

In situ generated aryl, heteroaryl, alkyl, or benzylic polyfunctional zinc reagents obtained by the addition of zinc and LiCl to the corresponding organic iodides undergo smooth Pd (0)- catalyzed cross-coupling reactions with aryl bromides, chlorides, and triflates in the presence of PEPPSI as a catalyst. This procedure avoids the manipulation of water and air- sensitive organozinc reagents and produces crosscoupling products in high yields.