e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Antitumor agents. 1. 1, 4-Bis [(aminoalkyl) amino]-9, 10-anthracenediones

KC Murdock, RG Child, PF Fabio…

Index: Murdock,K.C. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, # 9 p. 1024 - 1030

Full Text: HTML

Citation Number: 301

Abstract

The condensation of alkylenediamines with quinizarin or with 2, 3-dihydro-1, 4, 5, 8- tetrahydroxy-9, lO-anthracenedione, followed by oxidation, gave 1, 4-bis [(aminoalkyl) amino]-9, 1O-anthracenediones. Some of these compounds and their 2, 3-dihydro derivatives were markedly active against both leukemias and solid tumors in mice. Activity was maximal with 5, 8-dihydroxylation and 1, 4-bis [(2-aminoethy1) aminol substitution, in ...

Quinizarin Structure

N,N-DIMETHYL-1,4-BUTANEDIAMINE Structure

N,N-DIMETHYL-1,...

~%

1,4-Bis((4-(dimethylamino)butyl)amino)-9,10-anthracenedione Structure

1,4-Bis((4-(dim...

Quinalizarin Structure

~%

5,8-bis[2-(dimethylamino)ethylamino]-1,2-dihydroxyanthracene-9,10-dione Structure

5,8-bis[2-(dime...

1,4,5,6-tetrahydroxy-2,3-dihydroanthracene-9,10-dione Structure

1,4,5,6-tetrahy...

1,1-Dimethylethylenediamine Structure

1,1-Dimethyleth...

~%

5,8-bis[2-(dimethylamino)ethylamino]-1,2-dihydroxyanthracene-9,10-dione Structure

5,8-bis[2-(dime...

N-Acetylethylenediamine Structure

N-Acetylethylen...

9,10-Anthracenedione,2,3-dihydro-1,4,5,8-tetrahydroxy- Structure

9,10-Anthracene...

~%

N-[2-[[4-(2-acetamidoethylamino)-5,8-dihydroxy-9,10-dioxoanthracen-1-yl]amino]ethyl]acetamide Structure

N-[2-[[4-(2-ace...

Quinizarin Structure

N1,N1-DIMETHYLPENTANE-1,5-DIAMINE Structure

N1,N1-DIMETHYLP...

~%

1,4-Bis((5-(dimethylamino)pentyl)amino)-9,10-anthracenedione Structure

1,4-Bis((5-(dim...

Quinizarin Structure

3-Dimethylaminopropylamine Structure

3-Dimethylamino...

~%

1,4-bis[3-(dimethylamino)propylamino]anthracene-9,10-dione Structure

1,4-bis[3-(dime...

5-Methyl-2-benzofuran-1,3-dione Structure

5-Methyl-2-benz...

~%

1,4-bis[2-(dimethylamino)ethylamino]-6-methylanthracene-9,10-dione Structure

1,4-bis[2-(dime...

Hydroquinone Structure

~%

1,4-bis[2-(dimethylamino)ethylamino]-6-methylanthracene-9,10-dione Structure

1,4-bis[2-(dime...

N,N-Diisopropylethylenediamine Structure

N,N-Diisopropyl...

9,10-Anthracenedione,2,3-dihydro-1,4,5,8-tetrahydroxy- Structure

9,10-Anthracene...

~%

1,4-bis[2-[di(propan-2-yl)amino]ethylamino]-5,8-dihydroxyanthracene-9,10-dione Structure

1,4-bis[2-[di(p...

Quinizarin Structure

1,1-Dimethylethylenediamine Structure

1,1-Dimethyleth...

~%

9,10-Anthracenedione,1,4-bis[[2-(dimethylamino)ethyl]amino]- Structure

9,10-Anthracene...

9,10-Anthracenedione,2,3-dihydro-1,4,5,8-tetrahydroxy- Structure

9,10-Anthracene...

N,N-DIMETHYL-1,4-BUTANEDIAMINE Structure

N,N-DIMETHYL-1,...

~%

9,10-Anthracenedione, 1,4-bis[[4-(dimethylamino)butyl]amino]-5, 8-dihydroxy- Structure

9,10-Anthracene...

2-(N-methylanilino)ethylazanium Structure

2-(N-methylanil...

9,10-Anthracenedione,2,3-dihydro-1,4,5,8-tetrahydroxy- Structure

9,10-Anthracene...

~%

1,4-Dihydroxy-5,8-bis((2-(methylphenylamino)ethyl)amino)-9,10-anthrace nedione Structure

1,4-Dihydroxy-5...

9,10-Anthracenedione,2,3-dihydro-1,4,5,8-tetrahydroxy- Structure

9,10-Anthracene...

1,2-Ethanediamine Structure

1,2-Ethanediamine

~%

1,4-bis(2-aminoethylamino)-5,8-dihydroxyanthracene-9,10-dione Structure

1,4-bis(2-amino...

n-(2-hydroxypropyl)ethylenediamine Structure

n-(2-hydroxypro...

9,10-Anthracenedione,2,3-dihydro-1,4,5,8-tetrahydroxy- Structure

9,10-Anthracene...

~%

5,8-dihydroxy-1,4-bis[2-(2-hydroxypropylamino)ethylamino]anthracene-9,10-dione Structure

5,8-dihydroxy-1...