1 Et3N 2 condensation of primary sulfonamides with selected aldehydes, 1g-25 Scheme I. Although the direct condensation of primary sulfonamides with aldehydes has been conducted successfully with a variety of dehydrating agents (TiC14, 4-A molecular sieves, MgS04), 2, 1eN this approach has proven to be of limited value for nonenolizable ketones (0- 30%) and not applicable to enolizable or hindered ketones. lg In contrast, the homolytic ...
