2-Substituted azole derivatives. 1. Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl) benzimidazoles

…, K Yoshino, T Kohno, H Ohtaka, H Kagaya…

Index: Tsukamoto; Yoshino; Kohno; Ohtaka; Kagaya; Ito Journal of Medicinal Chemistry, 1980 , vol. 23, # 7 p. 734 - 738

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Citation Number: 71

Abstract

CHzCON NCHzCHzOH u tiaramide hydrochloride nonacidic antiinflammatory agent which inhibits acute inflammati~ n'~~ and the release of histamine and TXAz without affecting the cyclo-oxygenase system. 14b From the results listed in Tables I and 11, the following structureactivity relationships can be deduced. The parent compound is almost inactive; however, introduction of a lipophilic substituent at the 6 position of