Indian J. Chem. B

A domino type one-flask synthesis of 1-substituted-5-aminoimidazole-4-carboxamides and ring transformation to pyrazine under microwave through suitable …

G Chattopadhyay, TK Saha

Index: Chattopadhyay, Gautam; Saha, Tapas K. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 4 p. 827 - 830

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Abstract

Abstract: Reductive heterocyclisation of oximinocyanoacetamide 1 in the presence of ethyl orthoformate and appropriate amine affords 1-substituted-5-aminoimidazole-4- carboxamides 2. 4-Amino-5-carboxamido-3-diphenylmethyl-1-phenacylimidazolium bromide 4c, generated in situ from 2i, furnishes a ring expanded pyrazine derivative, 3-(1- amino-1-diphenylmethylamino) methyleno-2-oxo-6-phenylpyrazine 5 with methanolic ...