Tetrahedron Letters

A simple microwave-assisted preparation of 2-bromo-1-alkenes from 1-alkynes using the LiBr–TMSCl–TEAB reagent system

A Bunrit, S Ruchirawat, C Thongsornkleeb

Index: Bunrit, Anon; Ruchirawat, Somsak; Thongsornkleeb, Charnsak Tetrahedron Letters, 2011 , vol. 52, # 24 p. 3124 - 3127

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Citation Number: 6

Abstract

Abstract 2-Bromo-1-alkenes are cleanly and conveniently generated in good yields and selectivities via microwave-assisted hydrobromination of 1-alkynes using a combination of lithium bromide (LiBr), chlorotrimethylsilane (TMSCl), and tetraethylammonium bromide (TEAB) in acetonitrile (MeCN).

~40%

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