CuI/Pd0 Cooperative Dual Catalysis: Tunable Stereoselective Construction of Tetra??Substituted Alkenes

S Vercruysse, L Cornelissen, F Nahra…

Index: Vercruysse, Sebastien; Cornelissen, Loic; Nahra, Fady; Collard, Laurent; Riant, Olivier Chemistry - A European Journal, 2014 , vol. 20, # 7 p. 1834 - 1838

Full Text: HTML

Citation Number: 22

Abstract

Abstract This paper describes a tunable and stereoselective dual catalytic system that uses copper and palladium reagents. This cooperative silylcupration and palladium-catalyzed allylation readily affords trisubstituted alkenylsilanes. Fine-tuning the reaction conditions allows selective access to one stereoisomer over the other. This new methodology tolerates different substituents on both coupling partners with high levels of stereoselectivity. The ...