Synlett

The vinylogous mannich reaction: An efficient access to substituted nicotinonitriles

A Winter, N Risch

Index: Winter, Andreas; Risch, Nikolaus Synlett, 2003 , # 13 p. 1959 - 1964

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Citation Number: 5

Abstract

Abstract A straightforward method for the preparation of substituted nicotinonitriles has been developed. Starting from conjugated β-enaminonitriles and iminium salts, this methodology establishes a convenient access to 6-aryl-(5), 6-amino-(16) and 6-carboxylic ester- substituted derivatives 14 and as well to acetic acid-substituted pyrroles 12.