No-carrier-added (NCA) aryl [18 F] fluorides via the nucleophilic aromatic substitution of electron-rich aromatic rings

…, CY Shiue, JS Fowler, AP Wolf, A Plenevaux

Index: Ding, Y.-S.; Shiue, C.-Y.; Fowler, J. S.; Wolf, A. P.; Plenevaux, A. Journal of Fluorine Chemistry, 1990 , vol. 48, # 2 p. 189 - 205

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Citation Number: 82

Abstract

Abstract Nucleophilic aromatic substitution by [18 F] fluoride ion has been demonstrated on rings containing electron donating groups in addition to the necessary electron withdrawing and leaving groups. The reaction of 18 F− with a series of aromatic nitro aldehydes having protected hydroxyl substituents on the ring was studied. The reactivity of the aromatic ring towards nucleophilic substitution to give 18 F-labeled aromatic fluoroaldehyde derivatives ...