Tetrahedron letters

The Bohlmann–Rahtz route to functionalised pyridine scaffolds and their use in library synthesis

KE Bashford, MB Burton, S Cameron, AL Cooper…

Index: Bashford, Katherine E.; Burton, Matthew B.; Cameron, Stuart; Cooper, Anthony L.; Hogg, Rebecca D.; Kane, Peter D.; MacManus, David A.; Matrunola, Christopher A.; Moody, Christopher J.; Robertson, Avril A. B.; Warne, Mark R. Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1627 - 1629

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Citation Number: 39

Abstract

The Bohlmann–Rahtz reaction has been used to prepare 2, 3, 6-trisubstituted pyridines suitable for use in library synthesis. The synthesis of piperidine substituted nicotinic acid derivative 9 has been optimised and carried out on a large scale to give ca. 500 g of scaffold which was used in the generation of the pyridine library 11.