The a,@-unsaturated 0,s-acetals obtained via the reaction of methoxyphenylthiomethyl-lithium with 3-alkoxyenones are readily convertible into structurally diverse y-ketoesters by way of an efficient alkylation-hydrolysis sequence. ... Recently we required a concise and general procedure for the preparation of @-substituted-y-ketoesters (1) and their synthetic equivalents. Intermediates such as (1) were expected to be available by way of a three step sequence involving the ...
