Medicinal Chemistry Research

Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents

P Anand, B Singh

Index: Anand, Preet; Singh, Baldev Medicinal Chemistry Research, 2013 , vol. 22, # 4 p. 1648 - 1659

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Citation Number: 9

Abstract

Abstract This study was designed to synthesize and evaluate flavanone derivatives with phenylcarbamate moiety as potent acetylcholinesterase (AChE) inhibitors and anti-amnestic agents for management of AD. The synthesis of carbamate-substituted flavanone derivatives involved base-catalysed Claisen-Schmidt condensation reaction of 2-hydroxy acetophenone/2-hydroxy-4, 6-dimethoxyacetophenone with differently substituted ...