Analgesic study of novel pyrimidine derivatives linked with coumarin moiety

JK Gupta, PK Sharma, R Dudhe, A Chaudhary…

Index: Gupta, Jitendra Kumar; Sharma, Pramod K.; Dudhe, Rupesh; Chaudhary, Anshu; Singh, Avnesh; Verma; Mondal, Sambhu C.; Yadav, Rakesh Kumar; Kashyap, Shivjee Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1625 - 1632

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Citation Number: 16

Abstract

Abstract A novel series of 2-amino-4-(coumarin-3-yl)-6-substituted phenyl pyrimidines (5a– h) were synthesized from 3-acetylcoumarin (3). The structures of the synthesized compounds were elucidated by IR, 1 H NMR, 13 C NMR, and Mass spectroscopic techniques. The synthesized compounds were screened for in vivo analgesic activities at a dose of 20 mg/kg body weight (bw). Among them, compounds 5b and 5h exhibited ...