Identification of xanthones as selective killers of cancer cells overexpressing the ABC transporter MRP1

…, S Magnard, A Di Pietro, H Baubichon??Cortay…

Index: Genoux-Bastide, Estelle; Lorendeau, Doriane; Nicolle, Edwige; Yahiaoui, Samir; Magnard, Sandrine; DiPietro, Attilio; Baubichon-Cortay, Helene; Boumendjel, Ahcene ChemMedChem, 2011 , vol. 6, # 8 p. 1478 - 1484

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Citation Number: 25

Abstract

Abstract Multidrug-resistance protein 1 (MRP1) belongs to the ATP-binding cassette (ABC) transporter family. MRP1 mediates MDR (multidrug resistance) by causing drug efflux either by conjugation to glutathione (GSH) or by co-transport with free GSH (without covalent bonding between the drug and GSH). We recently reported that the calcium channel blocker verapamil can activate massive GSH efflux in MRP1-overexpressing cells, leading to cell ...