Synthesis, spectral studies and biological evaluation of a novel series of 2-substituted-5, 6-diarylsubstituted imidazo (2, 1-b)-1, 3, 4-thiadiazole derivatives as possible …

…, MN Noolvi, VS Maddi, M Ghatole, LG Nargund

Index: Palkar, Mahesh B.; Noolvi, Malleshappa N.; Maddi, Veeresh S.; Ghatole, Mangala; Nargund, Laxmivenkat G. Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1313 - 1321

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Citation Number: 13

Abstract

Abstract A novel series of 18 analogs of 2-substituted-5, 6-diarylsubstituted imidazo (2, 1-b)- 1, 3, 4-thiadiazole 6a–r have been synthesized by the reaction of 2-amino-5-substituted-1, 3, 4-thiadiazoles 5a–d and an appropriately substituted α-bromo-1, 2-(p-substituted) diaryl-1- ethanones 4a–e. Structures of these compounds were established by physiochemical, elemental analysis and spectral data. All the title compounds were tested for their in-vitro ...