European Journal of Organic Chemistry 2017-10-09

Unveiling the 6,8-Rearrangement in 8-Phenyl-5,7-dihydroxyflavylium and 8-Methyl-5,7-dihydroxyflavylium through Host–Guest Complexation

Nuno Basílio, João Carlos Lima, Luís Cruz, Victor de Freitas, Fernando Pina, Hiroki Ando, Yuki Kimura, Kin-Ichi Oyama, Kumi Yoshida

Index: 10.1002/ejoc.201701009

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Abstract

6,8-Rearrangement of the compounds 8-phenyl-5,7-dihydroxyflavylium and 8-methyl-5,7-dihydroxyflavylium is not observed at pH 1. However, the 6,8-rearrangement could be investigated by extending these studies to the moderately acidic region, in particular in the presence of a β-cyclodextrin derivative (captisol).