Design and bio-evaluation of indole derivatives as potent Kv1. 5 inhibitors

…, P Yu, Y Zhu, J Wei, W Chen, Y Zhang, X Zhang…

Index: Guo, Xiaoke; Yang, Qian; Xu, Jing; Zhang, Li; Chu, Hongxi; Yu, Peng; Zhu, Yingying; Wei, Jinglian; Chen, Weilin; Zhang, Yaozhong; Zhang, Xiaojin; Sun, Haopeng; Tang, Yiqun; You, Qidong Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6466 - 6476

Full Text: HTML

Citation Number: 8

Abstract

Abstract Atrial fibrillation (AF) is one of the common arrhythmias that threaten human health. Kv1. 5 potassium channel is reported as an efficacious and safe target for the treatment of AF. In this paper, we designed and synthesized three series of compounds through modifying the lead compound RH01617 that was screened out by the pharmacophore model we reported earlier. All of the compounds were evaluated by the whole-patch lamp ...