cis, cis, cis-1, 2, 3, 4-Tetrakis (diphenylphosphinomethyl) cyclopentane/1 2 [PdCl (C3H5)] 2 system catalyses efficiently the Heck reaction of heteroaryl halides with n-butyl acrylate, styrene, vinylpyridine and vinyl ether derivatives. High turnover numbers can be obtained for the reactions with halo pyridines, quinolines, furans or thiophenes.