Tetrahedron Letters

Metal-free n-Bu 4 NI-catalyzed direct synthesis of amides from alcohols and N, N-disubstituted formamides

H Li, J Xie, Q Xue, Y Cheng, C Zhu

Index: Li, Huamin; Xie, Jin; Xue, Qicai; Cheng, Yixiang; Zhu, Chengjian Tetrahedron Letters, 2012 , vol. 53, # 48 p. 6479 - 6482,4

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Citation Number: 34

Abstract

A facile and efficient protocol for the synthesis of amides has been developed in the absence of transition metals. The reaction was performed with a catalytic amount of n-Bu4NI and aqueous TBHP as an oxidant. Various alcohols with N, N-disubstituted formamides were examined to furnish the desired products in good yields.