Synthetic entries to 6??fluoro??7??substituted indole derivatives

…, A Failli, RJ Steffan, RM Soll, P Hughes…

Index: McKittrick, Brian; Failli, Amedeo; Steffan, Robert J.; Soll, Richard M.; Hughes, Philip; et al. Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2151 - 2163

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Citation Number: 27

Abstract

Abstract Three practical synthetic entries of functionalized 6-fluoro-7-substituted indole derivatives were developed in connection with the preparation of 7-fluoro-8-substituted-1, 3, 4, 9-tetrahydropyrano [3, 4-b] indole-1-acetic acid derivatives 11. The first route, which permits group modification about position 8 of the pyranoindole skeleton, employs 2-bromo- 3-fluoroaniline (18) as a key intermediate, the preparation of which was achieved by either ...