e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The direct formation of functionalized alkyl (aryl) zinc halides by oxidative addition of highly reactive zinc with organic halides and their reactions with acid chlorides,. …
L Zhu, RM Wehmeyer, RD Rieke
Index: Zhu, Lishan; Wehmeyer, Richard M.; Rieke, Reuben D. Journal of Organic Chemistry, 1991 , vol. 56, # 4 p. 1445 - 1453
Highly reactive zinc, prepared by the lithium naphthalenide reduction of ZnC12, readily undergoes oxidative addition to alkyl, aryl, and vinyl halides under mild conditions to generate the corresponding organozinc compounds in excellent yields. Significantly, the reaction will tolerate a spectrum of functional groups on the organic halides. Accordingly, this approach can now be used to prepare a wide variety of highly functionalized ...
