Stripping voltammetric methods for determination of the antiparasitic drug nitazoxanide in bulk form, pharmaceutical formulation and human serum

…, MM Ghoneim, MM Abdel-Galeil

Index: El-Desoky, Hanaa S.; Ghoneim, Mohamed M.; Abdel-Galeil, Mohamed M. Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 4 p. 669 - 679

Full Text: HTML

Citation Number: 16

Abstract

ABSTRACT Cyclic voltammograms of nitazoxanide recorded at the hanging mercury drop electrode in the Britton-Robinson universal buffer of pH values 2 to 11 containing 20%(v/v) ethanol exhibited a single 4-electron irreversible cathodic peak corresponding to the reduction of its NO 2 group to the hydroxylamine stage. Nitazoxanide was found to adsorb onto surface of the mercury electrode in a monolayer surface coverage of 3.16× 10-10 mol ...