Il Farmaco

Heterocyclic isosters of antimycobacterial salicylanilides

J Matyk, K Waisser, K Dražková, J Kuneš, V Klimešová…

Index: Matyk, Josef; Waisser, Karel; Drazkova, Katerina; Kunes, Jiri; Klimesova, Vera; Palat Jr., Karel; Kaustova, Jarmila Farmaco, 2005 , vol. 60, # 5 p. 399 - 408

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Citation Number: 22

Abstract

A series of 64 derivatives of substituted heterocyclic analogues of salicylanilides was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. For the QSAR study, the combination of Free–Wilson approach with Hansch approach was used. The molecules were separated on the heterocyclic and salicyl ...