e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Journal of medicinal chemistry

5-Piperazinylalkyl-2 (3H)-oxazolones with neuroleptic activity

G Cascio, E Manghisi, G Fregnan

Index: Cascio, Giuseppe; Manghisi, Elso; Fregnan, Giancarlo Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2241 - 2247

Full Text: HTML

Citation Number: 13

Abstract

2 (3H)-Oxazolones have received little attention as molecules of potential pharmacological interest; however, sedative and muscle relaxant activity were found to be associated with some 4-aryl-2 (3H)-oxazolones.'As part of a program aimed at discovering new series of therapeutically active compounds, a number of 4-aryl-2 (3H)-oxazolones bearing an aminoethyl group in the 5-position have been synthesized in our laboratories; ...

Potassium cyanate Structure

Potassium cyanate

N/A Structure

~%

4-(4-fluorophenyl)-5-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-3H-1,3-oxazol-2-one Structure

4-(4-fluorophen...

phosgene Structure

N/A Structure

~%

4-(4-fluorophenyl)-5-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-3H-1,3-oxazol-2-one Structure

4-(4-fluorophen...

Potassium cyanate Structure

Potassium cyanate

1-(4-fluorophenyl)-2-hydroxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one Structure

1-(4-fluorophen...

~%

Zoloperone Structure

phosgene Structure

1-(4-fluorophenyl)-2-hydroxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one Structure

1-(4-fluorophen...

~%

Zoloperone Structure

Potassium cyanate Structure

Potassium cyanate

N/A Structure

~%

Lodiperone Structure

phosgene Structure

N/A Structure

~%

Lodiperone Structure

Phenylisocyanate Structure

Phenylisocyanate

4'-fluoro-2-hydroxy-4-(4-phenylpiperazin-1-yl)butyrophenone Structure

4'-fluoro-2-hyd...

~%

4-(4-fluorophenyl)-3-phenyl-5-[2-(4-phenylpiperazin-1-yl)ethyl]-1,3-oxazol-2-one Structure

4-(4-fluorophen...

Potassium cyanate Structure

Potassium cyanate

4-(4-(2-chlorophenyl)piperazin-1-yl)-1-(4-fluorophenyl)-2-hydroxybutan-1-one Structure

4-(4-(2-chlorop...

~%

5-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-4-(4-fluorophenyl)-3H-1,3-oxazol-2-one Structure

5-[2-[4-(2-chlo...

phosgene Structure

4-(4-(2-chlorophenyl)piperazin-1-yl)-1-(4-fluorophenyl)-2-hydroxybutan-1-one Structure

4-(4-(2-chlorop...

~%

5-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-4-(4-fluorophenyl)-3H-1,3-oxazol-2-one Structure

5-[2-[4-(2-chlo...

Potassium cyanate Structure

Potassium cyanate

4'-fluoro-2-hydroxy-4-(4-phenylpiperazin-1-yl)butyrophenone Structure

4'-fluoro-2-hyd...

~%

4-(4-fluorophenyl)-5-[2-(4-phenylpiperazin-1-yl)ethyl]-3H-1,3-oxazol-2-one Structure

4-(4-fluorophen...

phosgene Structure

4'-fluoro-2-hydroxy-4-(4-phenylpiperazin-1-yl)butyrophenone Structure

4'-fluoro-2-hyd...

~%

4-(4-fluorophenyl)-5-[2-(4-phenylpiperazin-1-yl)ethyl]-3H-1,3-oxazol-2-one Structure

4-(4-fluorophen...

phosgene Structure

2-aminoethyldiethylamine Structure

2-aminoethyldie...

4'-fluoro-2-hydroxy-4-(4-phenylpiperazin-1-yl)butyrophenone Structure

4'-fluoro-2-hyd...

~%

3-[2-(diethylamino)ethyl]-4-(4-fluorophenyl)-5-[2-(4-phenylpiperazin-1-yl)ethyl]-1,3-oxazol-2-one Structure

3-[2-(diethylam...