Synthesis of Heterocyclic Compounds Using Amidines as Their Ene-1, 1-diamine Tautomers, IV: Synthesis of N-Bridged Heterocycles 1, 2, 3, 4-Tetrahydropyrido [1, 2- …

…, T Soma, D Yano, S Aikawa, Y Yoshida

Index: Ihara, Shogo; Soma, Takashi; Yano, Daigo; Aikawa, Shunichi; Yoshida, Yasuhiko Synthetic Communications, 2011 , vol. 41, # 24 p. 3600 - 3608

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Abstract

Abstract 2-Benzyl-1, 4, 5, 6-tetrahydropyrimidines 1 (as ene-1, 1-diamine N, C-tautomers) in diglyme reacted with ethyl benzoylacetate at 160° C in an oil bath to give 1, 2, 3, 4- tetrahydropyrido [1, 2-a] pyrimidin-6-ones 3 and with dimethyl acetylenedicarboxylate in methanol at room temperature, leading to methyl 1, 2, 3, 4-tetrahydropyrrolo [1, 2-a] pyrimidin-7-ylideneacetates 5, respectively.