Synthesis and serotonin transporter activity of sulphur-substituted α-alkyl phenethylamines as a new class of anticancer agents

…, AM Jørgensen, GH Peters, D Rai, D Corrigan…

Index: Cloonan, Suzanne M.; Keating, John J.; Butler, Stephen G.; Knox, Andrew J.S.; Jorgensen, Anne M.; Peters, Guenther H.; Rai, Dilip; Corrigan, Desmond; Lloyd, David G.; Williams, D. Clive; Meegan, Mary J. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 12 p. 4862 - 4888

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Citation Number: 10

Abstract

The discovery that some serotonin reuptake transporter (SERT) ligands have the potential to act as pro-apoptotic agents in the treatment of cancer adds greatly to their diverse pharmacological application. 4-Methylthioamphetamine (MTA) is a selective ligand for SERT over other monoamine transporters. In this study, a novel library of structurally diverse 4- MTA analogues were synthesised with or without N-alkyl and/or C-α methyl or ethyl ...