Synthesis of O-phosphorylated 1-substituted 2, 2, 2-trifluoroethanols, serine hydrolase inhibitors

AY Aksinenko, VB Sokolov, TV Goreva…

Index: Aksinenko; Sokolov; Goreva; Makhaeva Russian Chemical Bulletin, 2010 , vol. 59, # 1 p. 102 - 106

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Citation Number: 3

Abstract

Abstract Reactivity of trifluoromethyl carbonyl compounds in a two-step reaction with dialkyl phos-phites (the Abramov reaction and phosphonate—phosphate rearrangement) has been studied and the scope of this reaction for the preparation of O-phosphorylated 1-substituted 2, 2, 2-trifluoro-ethanols, serine hydrolase inhibitors, has been determined.