Esperamicins, a novel class of potent antitumor antibiotics. 3. Structures of esperamicins A1, A2, and A1b

…, G Groenewold, H Kawaguchi, M Konishi…

Index: Golik, Jerzy; Dubay, George; Groenewold, Gary; Kawaguchi, Hiroshi; Konishi, Masataka; et al. Journal of the American Chemical Society, 1987 , vol. 109, # 11 p. 3462 - 3464

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Citation Number: 301

Abstract

Figure 1. Structures of esperamicins A,, A,,, A,-absolute configuration of bicyclo [3.7. 1] core and trisaccharide portion arbitrarily chosen. which the double bond is at the bridgehead. It is the unique interaction of these three functionalities which most probably accounts for the extreme potency and activites observed. The complexity of the spectra of esperamicins la-c precluded a direct assignment of structure. Consequently a series of degradations of la ...