A Facile Synthesis of N-Carboxyanhydrides and Poly (α-amino acid) Using Di-tert-butyltricarbonate

A Nagai, D Sato, J Ishikawa, B Ochiai, H Kudo…

Index: Nagai, Atsushi; Sato, Daisuke; Ishikawa, Junichi; Ochiai, Bungo; Kudo, Hiroto; Endo, Takeshi Macromolecules, 2004 , vol. 37, # 7 p. 2332 - 2334

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Citation Number: 30

Abstract

The chemistry of amino acids and peptides is important in the structural elucidation and synthesis of oligoand polypeptides with useful biological function. 1 We can now obtain optically pure amino acids for low prices due to recent remarkable improvements in the technology in fermentation and organic synthesis. Consequently, amino acids and some oligopeptides are now widely used for drug, food, chiral sources in organic synthesis, and ...