Tetrahedron

Straightforward three-component synthesis of diarylmethylpiperazines and 1, 2-diarylethylpiperazines

S Sengmany, E Le Gall, C Le Jean, M Troupel…

Index: Sengmany, Stephane; Le Gall, Erwan; Le Jean, Cedric; Troupel, Michel; Nedelec, Jean-Yves Tetrahedron, 2007 , vol. 63, # 18 p. 3672 - 3681

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Citation Number: 23

Abstract

Several functionalized diarylmethylpiperazines and 1, 2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or β-arylethylpiperazines toward the use of paraformaldehyde or aliphatic ...