Thiophene isosteres: synthesis and pharmacological study of 3-(azol-1-yl) thieno isothiazole-1, 1-dioxides

…, R Madroñero, JA Diaz, F Junquera, J Alonso…

Index: Vega, Salvador; Madronero, Ramon; Diaz, J. Antonio; Junquera, Francisco; Alonso, Javier; et al. European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 329 - 334

Full Text: HTML

Citation Number: 18

Abstract

This document does not have an outline. ... JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. ... Author links open the overlay panel. Numbers correspond to the affiliation list which can be exposed by using the show more link. ... Three series of new 3-(azol-1-yl)thieno isothiazole-1,1-dioxides were synthesized and tested for anti-inflammatory and related pharmacological activities as well as for acute toxicity. ...

 Related Synthetic Route
Methyl 3-chlorosulfonylthiophene-2-carboxylate Structure

59337-92-7

Methyl 3-chloro...

~%

3-(3,5-dimethylpyrazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-68-1

3-(3,5-dimethyl...

Methyl 3-sulfamoyl-2-thiophenecarboxylate Structure

59337-93-8

Methyl 3-sulfam...

~%

3-(3,5-dimethylpyrazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-68-1

3-(3,5-dimethyl...

thieno[2,3-d]isothiazol-3(2H)-one 1,1-dioxide(SALTDATA: FREE) Structure

59337-94-9

thieno[2,3-d]is...

~%

3-(3,5-dimethylpyrazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-68-1

3-(3,5-dimethyl...

3,5-Dimethylpyrazole Structure

67-51-6

3,5-Dimethylpyrazole

thieno[2,3-d]isothiazol-3(2H)-one 1,1-dioxide(SALTDATA: FREE) Structure

59337-94-9

thieno[2,3-d]is...

~42%

3-(3,5-dimethylpyrazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-68-1

3-(3,5-dimethyl...

Methyl 3-amino-5-phenyl-2-thiophenecarboxylate Structure

100063-22-7

Methyl 3-amino-...

~%

3-(3,5-dimethylpyrazol-1-yl)-5-phenylthieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-73-8

3-(3,5-dimethyl...

Methyl 3-sulfamoyl-2-thiophenecarboxylate Structure

59337-93-8

Methyl 3-sulfam...

~83%

thieno[2,3-d]isothiazol-3(2H)-one 1,1-dioxide(SALTDATA: FREE) Structure

59337-94-9

thieno[2,3-d]is...

Methyl 3-amino-5-phenyl-2-thiophenecarboxylate Structure

100063-22-7

Methyl 3-amino-...

~%

3-indazol-1-yl-5-phenylthieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

119120-84-2

3-indazol-1-yl-...

Methyl 3-chlorosulfonylthiophene-2-carboxylate Structure

59337-92-7

Methyl 3-chloro...

~%

3-(4-chloro-3,5-dimethylpyrazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-69-2

3-(4-chloro-3,5...

Methyl 3-sulfamoyl-2-thiophenecarboxylate Structure

59337-93-8

Methyl 3-sulfam...

~%

3-(4-chloro-3,5-dimethylpyrazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-69-2

3-(4-chloro-3,5...

thieno[2,3-d]isothiazol-3(2H)-one 1,1-dioxide(SALTDATA: FREE) Structure

59337-94-9

thieno[2,3-d]is...

4-Chloro-3,5-dimethyl-1H-pyrazole Structure

15953-73-8

4-Chloro-3,5-di...

~43%

3-(4-chloro-3,5-dimethylpyrazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

113387-69-2

3-(4-chloro-3,5...

Methyl 3-chlorosulfonylthiophene-2-carboxylate Structure

59337-92-7

Methyl 3-chloro...

~%

3-(benzotriazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

119120-83-1

3-(benzotriazol...

Methyl 3-sulfamoyl-2-thiophenecarboxylate Structure

59337-93-8

Methyl 3-sulfam...

~%

3-(benzotriazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

119120-83-1

3-(benzotriazol...

thieno[2,3-d]isothiazol-3(2H)-one 1,1-dioxide(SALTDATA: FREE) Structure

59337-94-9

thieno[2,3-d]is...

1H-Benzotriazole Structure

95-14-7

1H-Benzotriazole

~43%

3-(benzotriazol-1-yl)thieno[2,3-d][1,2]thiazole 1,1-dioxide Structure

119120-83-1

3-(benzotriazol...


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