Tetrahedron Letters

Hexabromoacetone and ethyl tribromoacetate: a highly efficient reagent for bromination of alcohol

P Tongkate, W Pluempanupat, W Chavasiri

Index: Tongkate, Pratoomrat; Pluempanupat, Wanchai; Chavasiri, Warinthorn Tetrahedron Letters, 2008 , vol. 49, # 7 p. 1146 - 1148

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Citation Number: 24

Abstract

A new and efficient method for the bromination of alcohols utilizing Br3CCOCBr3/PPh3 and Br3CCO2Et/PPh3 is described. Various alcohols can be converted smoothly into their corresponding alkyl bromides in high yields under mild conditions with short reaction times. Based upon 1H NMR studies using competitive reactions between selected brominating agents and Cl3CCN, Br3CCOCBr3 displays the highest reactivity approximately nine ...