Novel and potent anti-malarial agents

KM Brinner, JM Kim, H Habashita, IY Gluzman…

Index: Brinner, Kristin M; Mi Kim, Jin; Habashita, Hiromu; Gluzman, Ilya Y; Goldberg, Daniel E; Ellman, Jonathan A Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 11 p. 3649 - 3661

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Citation Number: 33

Abstract

Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70–350 nM against chloroquine-resistant strains of Plasmodium falciparum.