Tetrahedron letters

One-step synthesis of 2-arylbenzothiazole ('BTA') and-benzoxazole precursors for in vivo imaging of β-amyloid plaques

D Alagille, RM Baldwin, GD Tamagnan

Index: Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D. Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1349 - 1351

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Citation Number: 132

Abstract

We report the simple and efficient synthesis of 2-arylbenzothiazoles ('BTA') and 2- arylbenzoxazoles by direct coupling of benzothiazoles or benzoxazoles with aryl bromides. This method permits direct one-step access to precursors of radiolabeled BTA-1 and BTA-2 and their 6-methoxy analogues, used for in vivo imaging of β-amyloid plaques with positron emission tomography (PET).