Studies on Nonpeptide Angiotensin II Receptor Antagonists. I. Synthesis and Biological Evaluation of Pyrazolo (1, 5-b)(1, 2, 4) triazole Derivatives with Alkyl …

T Okazaki, A Suga, T Watanabe, K KIKUCHI…

Index: Chemical and Pharmaceutical Bulletin, , vol. 46, # 1 p. 69 - 78

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Abstract

... Chemistry The key intermediates (12) were prepared by follow- ing a literature route“) (Chart 1). 3 ... tert-butoxide as a base gave the N(l)-isomers (13) and © 1998 Pharmaceutical Society of ... l)- and N(5)-isomers could be confirmed from the 1H-NMR spectra (higher chemical shift of ...