Synthesis of syn and anti isomers of 6-[[(hydroxyimino) phenyl] methyl]-1-[(1-methylethyl) sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus multiplication

…, CJ Paget, DC DeLong, JD Nelson…

Index: Wikel, J. H.; Paget, C. J.; DeLong, D. C.; Nelson, J. D.; Wu, C. Y. E.; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 368 - 372

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Citation Number: 87

Abstract

Diwan et aL4 indicated that this activity was due to a direct effect on the host cell. Hollinshead and Smith5 discovered the activity of 2-(a-hydroxybenzyl) benzimidazole (HBB) which has been proven to be a virus-specific inhibitor6p7 and to induce or to select resistant mutants also indicating a virus-specific actioms O'Sullivan and Wallisg reported the evaluation of 1, 2-bis (2-benzimidazolyl)-l, 2-ethanediol. This was followed by the ...