Synthesis, Characterization, and Biological Evaluation of a Dual??Action Ligand Targeting αvβ3 Integrin and VEGF Receptors

…, M Mingozzi, A Dal Corso, R Fanelli, D Arosio…

Index: Mingozzi; Manzoni; Arosio; Dal Corso; Manzotti; Innamorati; Pignataro; Lecis; Delia; Seneci; Gennari Organic and Biomolecular Chemistry, 2014 , vol. 12, # 20 p. 3288 - 3302

Full Text: HTML

Citation Number: 2

Abstract

Abstract A dual-action ligand targeting both integrin α V β 3 and vascular endothelial growth factor receptors (VEGFRs), was synthesized via conjugation of a cyclic peptidomimetic α V β 3 Arg-Gly-Asp (RGD) ligand with a decapentapeptide. The latter was obtained from a known