Synthesis of α, α??Difluoro?螃漫?amino Esters or gem??Difluoro?螃漫?lactams as Potential Metallocarboxypeptidase Inhibitors

…, P Gloanec, G De Nanteuil, P Jubault…

Index: Boyer, Nicolas; Gloanec, Philippe; De Nanteuil, Guillaume; Jubault, Philippe; Quirion, Jean-Charles European Journal of Organic Chemistry, 2008 , # 25 p. 4277 - 4295

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Citation Number: 28

Abstract

Abstract The synthesis of gem-difluorinated β-lactams and gem-difluorinated β-amino acids, each possessing a potential basic functional group, from ethyl bromodifluoroacetate and either imines (for β-lactams) or N-(α-aminoalkyl) benzotriazoles (for β-amino esters) was investigated. A series of these compounds were used for the design of novel metallocarboxypeptidase inhibitors. N-Alkylation and N-acylation of these two versatile ...