European Journal of Organic Chemistry

Methyl 2??Furoate: An Alternative Reagent to Furan for Palladium??Catalysed Direct Arylation

HY Fu, H Doucet

Index: Fu, Hai Yan; Doucet, Henri European Journal of Organic Chemistry, 2011 , # 35 p. 7163 - 7173

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Citation Number: 13

Abstract

Abstract The palladium-catalysed direct arylation of methyl 2-furoate with aryl bromides was studied. The use of KOAc as the base, dimethylacetamide (DMAc) as the solvent and Pd (OAc) 2 as the catalyst was found to give 5-arylfurans regioselectively and without decarboxylation. These methyl 5-aryl-2-furoates gave 2, 5-diarylfurans by decarboxylative coupling by using Pd (OAc) 2 as the catalyst. Methyl 2-furoate thus represents a ...