6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators

A Sharon, R Pratap, R Vatsyayan, PR Maulik…

Index: Sharon, Ashoke; Pratap, Ramendra; Vatsyayan, Rit; Maulik, Prakas R.; Roy, Uma; Goel, Atul; Ram, Vishnu Ji Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3356 - 3360

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Citation Number: 9

Abstract

Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2, 4-thiazolidinedione head group to express potent PPAR-γ transactivation response. Some of the screened compounds have shown promising PPAR-γ agonistic activity.

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6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PP...

[Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 14 p. 3356 - 3360]