Abstract To find novel compounds against H 5 N 1, three series of known or novel small molecular polyphenols were synthesized and tested in vitro for anti-H 5 N 1 activity. In addition, the preliminary structure–antiviral activity relationships were elaborated. The results showed that some small molecular polyphenols had better anti-H 5 N 1 activity, and could serve as novel virus entry inhibitors against H 5 N 1, likely targeting to HA2 protein. ...
